AAA237, AN SKP2 INHIBITOR, SUPPRESSES GLIOBLASTOMA BY INDUCING BNIP3-DEPENDENT AUTOPHAGY THROUGH THE MTOR PATHWAY

AAA237, an SKP2 inhibitor, suppresses glioblastoma by inducing BNIP3-dependent autophagy through the mTOR pathway

Abstract Background Glioblastoma (GBM) is the most common brain tumor with the worst prognosis.Temozolomide is kit purge campagnolo the only first-line drug for GBM.Unfortunately, the resistance issue is a classic problem.Therefore, it is essential to develop new drugs to treat GBM.As an oncogene, Skp2 is involved in the pathogenesis of various can

read more

Das papierlose Parlament

Digitalisation covers and is changing all areas of our lives.That is why even ceramic baffle board members of parliament have discussed the issue of digital parliamentary functions.Digitalisation is, however, only a meaningful goal to jumbo tuz de?irmeni be desired if it provides clear added value for the members of parliament in exercising their m

read more


Ten simple rules for making a vocabulary FAIR.

We present ten simple rules that support converting a legacy vocabulary-a list of terms available in a print-based glossary or in a table not accessible using web standards-into a FAIR ceramic baffle board vocabulary.Various pathways may be followed to publish the FAIR vocabulary, but we emphasise particularly the goal of providing a globally uniqu

read more