AAA237, an SKP2 inhibitor, suppresses glioblastoma by inducing BNIP3-dependent autophagy through the mTOR pathway
Abstract Background Glioblastoma (GBM) is the most common brain tumor with the worst prognosis.Temozolomide is kit purge campagnolo the only first-line drug for GBM.Unfortunately, the resistance issue is a classic problem.Therefore, it is essential to develop new drugs to treat GBM.As an oncogene, Skp2 is involved in the pathogenesis of various can